Keep in mind that a "gain pedal" like the Blue OD will amplify any incoming noise, no matter the source. Some common noise sources include power supplies, single coil pickup 60 Hz hum, noise from other pedals in your signal chain, electrical interference from nearby devices like fluorescent lights or space heaters, etc.
The first thing I'd try is to power the pedal with a 9V battery and run a humbucker guitar through just the Blue OD into your amp, followed by just the guitar straight into the amp. That should give you a pretty good idea of any noise being added by the pedal itself.
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